DOI: 10.36347/sjams.2017.v05i05.030

Pages: 1866-1874

Atherosclerosis begins with damage to the endothelium. It’s caused by high blood pressure, smoking, or high cholesterol. That damage leads to the formation of plaque. When bad cholesterol, or LDL, crosses the damaged endothelium, the cholesterol enters the wall of the artery. That causes your white blood cells to stream in to digest the LDL. Over years, cholesterol and cells become plaque in the wall of the artery. This was a prospective case control study conducted between June to August 2016 in the Department of Pathology in collaboration with Department of Cardiology, General medicine and Department of Biochemistry of Prathima Institute of Medical Sciences, Karimnagar. The study and control groups were found to be age and sex matched statistically. Hence, no bias in the results was observed due to age and sex in the results. Out of the total 80 cases of hyperlipidemia, 47 were males and 33 were females. The patients fell into the age group between 23 to 83 years. Mean age in study group - 53.65 years and in control group - 56.35. All three PVI were significantly higher in hyperlipidemic cases than the normolipidemic controls (p-value <0.05). Isolated hyperlipidemia showed no significant difference in platelet parameters than controls (p-value >0.05). Hyperlipidemia associated with other diseases like diabetes, hypertension and CAD showed significantly lower platelet counts and significantly higher platelet indices (p-value <0.05) than controls.