DOI: 10.36347/sjams.2017.v05i05.033

Pages: 1879-1882

The objective is to study of insulin secretory response after oral glucose load in smokers. Study was conducted on normal BMI matched healthy 40 nonsmokers and 60 smokers (divided into 3 groups according to amount of smoking) of age group of 20-50 years. venous blood was drawn after an overnight fasting and fasting blood sugar level, at ½ hour,1 hour , 1 ½ hour and 2 hour after an oral glucose load of 75 gm and Serum insulin estimation (radio- immune assay method) After 75 gm oral glucose load at ½ hour,1 hour , 1 ½ hour and 2 hours interval are estimated. Smokers have relatively increased blood glucose levels and hyperinsulinemia as compared to non-smokers. Smoking is associated with relative glucose intolerance, hyperinsulinemia and a slower insulin response which is independent of age and BMI. The alteration is directly proportional to the amount of smoking.