DOI: 10.36347/sjams.2017.v05i05.040

Pages: 1911-1914

Haemoglobinopathies constitute a very important causative factor for anaemias of childhood. The two common haemoglobinopathies widely distributed across our country are the beta thalassemic syndromes and sickling disorders. The present study is carried out with a view to assess magnitude of these disorders in our area by haemoglobin electrophoresis and to evaluate the utility of NESTROFT as screening test of Thalassemia minor, to evaluate HbA2 level by electrophoresis with clinical and hematological parameters, and to find out other haemoglobinopathies associated with thalassemia. The present study was carried out during the period of 2 years from September 2014 to September 2016. During this total 200 cases were studied. NESTROF carried 94.28% sensitivity, 92.72% specificity, 73.33% positive predictive value (PPV) and 98.70% negative predictive value (NPV) in detecting β thalassemia trait in present study. MENTZER Index < 12 carried 88.57% sensitivity, 97.57% specificity, 88.57% PPV and 97.57% NPV in detecting β thalassemia trait in present study. NESTROF is a simple, cheap, easy and rapid method of mass screening programme of thalassemia detection has quite acceptable sensitivity and specificity. But negative test in high risk community must be repeated and confirmation must be done by other confirmatory tests. Thalassemia is associated with many other haemoglobinopathies. In this study, common association with Sickle cell disease was found. For marriages, instead of matching HOROSCOPE of Brides and Groom, thalassemia test should be done. It will be a great help to mankind by preventing the “THALASSEMIA MAJOR” and giving birth to healthy baby and healthy society.