DOI: 10.36347/sjams.2017.v05i05.042

Pages: 1920-1925

Hypertensive disorders of pregnancy remain a major health issue for women and their infants. A transient and potentially dangerous complication of pregnancy is Preeclampsia. Despite intensive research being undertaken worldwide, the etiology of pregnancy induced hypertension is still unknown. Various studies have claimed that lipid abnormalities and alteration in the serum levels of essential minerals like sodium, potassium, calcium and magnesium have relevant roles in the etiopathogenesis and severity of preeclampsia. So this study was aimed to determine the role of serum lipid levels and minerals in the pathogenesis and severity of preeclampsia. In this study serum lipid profile (which includes total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol, HDL cholesterol) and minerals (sodium, potassium, total calcium, magnesium) were measured in 30 women in the third trimester of pregnancy with mild preeclampsia , 20 women in the third trimester of pregnancy with severe preeclampsia and compared statistically with 50 healthy age and sex matched normotensive women in the third trimester of pregnancy by Student t-test and Anova in SPSS version 17.0. In lipid levels serum triglycerides, total cholesterol and LDL-C were all found to have significant positive correlation, while HDL-C were found to be negatively correlated with the severity of preeclampsia. Among the essential minerals, serum sodium, calcium and magnesium levels showed significant negative correlation with the severity of preeclampsia but serum potassium was found to have no significant relationship in preeclamptic women and normal pregnant women. From the above study it is concluded that dyslipidemia and reduced mineral levels might contribute for the development of preeclampsia. So early detection and appropriate supplementation may reduce the incidence and severity of preeclampsia.