DOI: 10.36347/sjams.2017.v05i05.058

Pages: 2003-2007

There are number of newly developed antiepileptic drugs are currently in use, among them Lamotrigine (LTG) is more common. It is extensively used to control the generalized seizures and myoclonic seizures; it has not been possible to predict the teratogenic effects of LTG. The current study was designed to find out the teratogenic effects of Lamotrigine on heart and liver of developing chick embryo. Experimental eggs were injected with single injection of 2mg/egg therapeutic dose and 4mg/egg double the therapeutic dose. Histological examination of the liver revealed dilated central veins with degenerated hepatocytes with disturbed cellular architecture. Longitudinal sections of the heart showed thickened ventricular musculature with narrower lumen and haemorrhagic spots over atrial musculature.