DOI: 10.36347/sjams.2017.v05i04.075

Pages: 1617-1620

Cirrhosis is the end stage consequence of fibrosis of hepatic parenchyma, resulting in nodule formation that may lead to altered hepatic function and blood flow. There are a wide variety of tests to evaluate the severity of liver dysfunction .One simple, non- expensive and reliable test to foretell severity of hepatic injury is the serum lipid profile. The aim was to determine the lipid profile in cirrhotic patients and to assess if there is correlation between the lipid profile derangement and severity of liver dysfunction. 50 cases of cirrhosis were recruited from patients attending the liver clinic in the department of medical gastroenterology in the age group of 30 to 70 years. Patients with Diabetes, renal failure, acute pancreatitis and with history of hyperlipidemia are excluded. 50 age matched healthy controls were selected. Fasting blood sample was collected and lipid profile was done using enzymatic method. Child-Pugh score and The Model for End-Stage Liver Disease, or MELD were used for assessing the severity of liver disease. In our study, it was found that all the four variables (Total cholesterol, Triglycerides, LDL and HDL) were significantly decreased in patients compared to normal subjects. Among these parameters total cholesterol, LDL, HDL correlated inversely well with the severity of liver dysfunction. Since metabolism of serum lipids is predominantly accomplished by liver, it is probable that lipid profile can be used as a laboratory marker of severity of liver damage in cirrhosis, a non- expensive easy test to foretell severity of hepatic injury.