DOI: 10.36347/sajp

Pages: 138-144

The present work deals with the preparation of Perindopril erbumine ethosomes and study of effect of alcohol and phospholipid on transdermal delivery. Perindopril erbumine is ACE inhibitor which slowly inhibits the activity of the enzyme ACE, which decreases the production of angiotensin II. As a result, the blood vessels enlarge or dilate, and blood pressure is reduced. Perindopril erbumine loaded ethosomes were prepared by hot method by using different concentrations of Alcohol and Soya lecthin in different ratios and propylene glycol. The prepared ethosomal formulations were evaluated for Vesicle size analysis, Morphological studies, Entrapment efficiency, In vitro release, Stability studies, In vitro permeation study and kinetic data analysis. The vesicle size of ethosomes varied between 1.62± 1.31 µm to 4.56±0.08µm. Entrapment efficiency between 54.81±0.30 to 78.04±0.30%. FT-IR, DSC and Zeta potential studies revealed the integrity of the drug in the formulations. The cumulative percentage drug release from ethosomal formulations ETH1 to ETH6 was in the range of 71.52% to 85.75%. and for LPH it was 50.20±0.23%. The in vitro permeation across rat abdominal skin for the optimized formulations ETH3 and ETH6 after 24 hrs was found to be 75.46% and 80.24% respectively. Stability studies indicated that, the prepared ethosomes remained stable at refrigeration (4-8˚C) and room (25±2˚C) temperature. The prepared ethosomes showed promising results under in vitro conditions.