DOI: 10.36347/gamj.2023.v04i01.003

Pages: 17-23

This study evaluated the curative and prophylactic antiplasmodial potential of ethanol extract of Moringa oleifera seed. Seventy mice, weighing 20-30grams were used for the study. The mice were divided into seven groups (A-G) of five rats each. Groups A-F were the treatment groups, while group G was the control group. The mice were inoculated with Plasmodium berghei and then treated with standard antimalarial drugs (A, B and C) and 200mg/kg, 300mg/kg and 500mg/kg (D, E and F). The mice were treated for three days. Thereafter, blood films were made from the mice, dried, stained and viewed using x10 lens. The % parasitaemia and chemosuppression were determined. The ethanol extract significantly reduced the % parasitaemia in the treated mice, compared to the control group. However, the effects of the extract at the doses used for the study were less comparable to those of the standard drugs used for this study. The ethanol extract of Moringa seed has both curative and prophylactic antiplasmodial potential. However, these effects were less comparable to those of the standard drugs used for the study. It is recommended that the extract be considered for use as an antiplasmodial agent.