DOI: 10.36347/sajp

Pages: 199-207

The main objective of the present work was to develop sustained release matrix tablets of water soluble Tramadol hydrochloride using different polymers viz. Hydroxy propyl methyl cellulose (HPMC) and natural gums like gumkodangogu. drug and polymer for control the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material and triple mixture of three different rate controlling material. After evaluation of physical properties of tablet, the in vitro release study was performed in0.1 N HCl . The effect of polymer concentration and polymer blend concentration were studied. .Dissolution data was analyzed by KorsmeyerPeppas power law expression and modified power law expression. It was observed that matrix tablets contained polymer blend of kodangogu/HPMC were successfully sustained the release of drug upto 10 hrs. Among all the formulations, formulation F6 which contains HPMC K15M and of kodangogu release the drug which follow Zero order kinetics via, swelling, diffusion and erosion and the release profile of formulation F6 was comparable with the marketed product. Stability studies (40±2ºC/75±5%RH) for 3 months indicated that Tramadol hydrochloride was stable in the matrix tablets. The FTIR study revealed that there was no chemical interaction between drug and excipients.