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Scholars Journal of Applied Medical Sciences | Volume-11 | Issue-01
Immunohistochemical Expression of Cath-D as Prognostic Biological Marker and its Correlation with Clinical and Histopathological Parameters in Human Breast Cancer
Dr. Sabah Ali Mugahed Al-Qadasi, Mona Abd Alhamed Yahia, Saeed Mahmoud Saeed Mohamed, Roa Mohmed Mahmoud Sultan
Published: Jan. 13, 2023 |
157
125
DOI: 10.36347/sjams.2023.v11i01.012
Pages: 60-73
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Abstract
Cathepsin D (Cath-D) is a soluble lysosomal aspartyl glycoprotease that can degrade the protein components of the matrix and free growth factors therein embedded, thus favoring tumor growth, invasion and angiogenesis. The aim of the present work was to investigate the expression of Cathepsin D as novel prognostic biomarker in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues as well as their correlation with different pathological and histological parameters. Immunohistochemical technique was used to examine the expression of Cath-D in normal, benign as well as in IDC. Present results showed higher expression of Cath-D in IDC comparing to normal and benign breast tissues.