DOI: 10.36347/sasjs.2023.v09i01.005

Pages: 18-20

Duodenal GISTs are rare mesenchymal neoplasms of the gastrointestinal tract. The usual presentation is gastrointestinal bleeding or abdominal pain. They can be asymptomatic until they reach a considerable size. Tyrosine kinase inhibitors (TKI) are important in high risk GISTs and in locally advanced disease. We report a 65-year-old man with abdominal discomfort, anemia and clinically palpable abdominal mass. A Computed Tomography (CT) scan of the abdomen and pelvis was done which showed a locally advanced duodenal GIST involving second and third part of duodenum. Neoadjuvant imatinib was given to this patient for 6 months. He underwent Whipple’s procedure and right hemicolectomy. The histopathological examination report revealed a high-risk duodenal GIST. Adjuvant Imatinib was continued for 1 month after the operation. He continued to do well with no evidence of disease recurrence based on post-operative CT abdomen and pelvis.