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Scholars Academic Journal of Pharmacy | Volume-4 | Issue-04
Atherogenic Dyslipidemia andits Management in Diabetes
Jimimol Thomas, K. Krishnakumar, L. Panayappan, K. Jayapraksah
Published: April 29, 2015 |
109
152
DOI: 10.36347/sajp
Pages: 245-248
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Abstract
Atherogenic dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. The
characteristic features of diabetic dyslipidemia are a high plasma triglyceride concentration, low HDL cholesterol
concentration and increased concentration of small dense LDL-cholesterol particles. The lipid changes associated with
diabetes mellitus are attributed to increased free fatty acid flux secondary to insulin resistance. In patients treated with a
statin to LDL-cholesterol goals, the addition of ezetimibe, fenofibrate, niacin, or n-3 fatty acid ethyl esters may be
required to correct the persistent atherogenic dyslipidemia