DOI: 10.36347/sajp

Pages: 340-346

The ocular drug delivery system is considered as crucial and challenging as the delivery of drug is quite difficult. Moreover, the conventional opthalmic formulations exhibit a short pre-corneal residence time and poor bioavailability . Various attempts have been made towards the development of stable sustained release in-situ gels. Newer research in ophthalmic drug delivery systems is directed towards a incorporation of several drug delivery technologies, that includes to build up systems which is not only extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug. This is a review on ocular in situ gels, delivery systems, evaluation and application