![](/static/media/logo.jpg)
An International Publisher for Academic and Scientific Journals
Author Login
Scholars Academic Journal of Pharmacy | Volume-5 | Issue-04
Quantification Assay of Methoxsalen from Bulk Dosage Form by UVSpectrometry Method
Manisha B. Parhad
Published: April 28, 2016 |
122
157
DOI: 10.36347/sajp
Pages: 83-86
Downloads
Abstract
Rapid, specific and economic UV spectrophotometric method has been developed to determine the
methoxsalen content in bulk and pharmaceutical dosage formulations. At a pre-determined λ max of 247nm,it was
proved linear in the range of 1.0–12.0 mg/mL, and exhibited good correlation coefficient (R2-0.999 .This method was
successfully applied to the determination of methoxsalen content in marketed brand(Melanocyl R2-0.982, Meladerm R2-
0.971) and the results were in good agreement with the label claims. Methoxsalen is a photosensitizing agent which has
a chemical structure susceptible to degradation. The obtained results proved that the method can be employed for the
routine analysis of methoxsalen in bulks as well as in the commercial formulations.