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Scholars Academic Journal of Pharmacy | Volume-5 | Issue-04
Anti inflammatory activity of Methanolic stem extract of Tephrosia purpurea.
Atul Kumar Gangwar, Ashoke K. Ghosh
Published: April 28, 2016 |
243
192
DOI: 10.36347/sajp
Pages: 92-94
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Abstract
Tephrosia purpurea L. plant is used in the indigenous system of medicine, belonging to the Family Fabaceae.
To study the anti-inflammatory activity of methanolic stem extract of T. purpurea by using Carrageenan induced model.
Anti-inflammatory activity of methanolic stem extract of T. purpurea was studied, in which inflammation was induced
by injecting 0.1ml of 1 per cent Carrageenan in to the sub plantar side of the left hind paw. Test drugs were administered
in a dose of 10, 20 and 40 mg/kg (body weight) one hour before commencing the experiment. The anti-inflammatory
activity was assessed by determining and comparing the paw volume (ml) in the test drug group with that of the vehicle
control group. Diclofenac sodium 5 mg/kg (body weight) was used as a reference drug. Inflammation in the methanolic
stem extract of T. purpurea treated animals was found to be significantly less compared to vehicles control animals.
Diclofenac sodium (5 mg/kg body weight) produces significant reduction in inflammation when compared to control
group. Methanolic stem extract of T. purpurea (M.S.E.T.) produced significant anti-inflammatory activity. Our results
suggest that all the Methanolic stem extract of T. purpurea (M.S.E.T.) possess significant anti-inflammatory activity.
Among the three doses of T. purpurea 40 mg/kg body weight showed maximum activity.