DOI: 10.36347/sajp

Pages: 92-94

Tephrosia purpurea L. plant is used in the indigenous system of medicine, belonging to the Family Fabaceae. To study the anti-inflammatory activity of methanolic stem extract of T. purpurea by using Carrageenan induced model. Anti-inflammatory activity of methanolic stem extract of T. purpurea was studied, in which inflammation was induced by injecting 0.1ml of 1 per cent Carrageenan in to the sub plantar side of the left hind paw. Test drugs were administered in a dose of 10, 20 and 40 mg/kg (body weight) one hour before commencing the experiment. The anti-inflammatory activity was assessed by determining and comparing the paw volume (ml) in the test drug group with that of the vehicle control group. Diclofenac sodium 5 mg/kg (body weight) was used as a reference drug. Inflammation in the methanolic stem extract of T. purpurea treated animals was found to be significantly less compared to vehicles control animals. Diclofenac sodium (5 mg/kg body weight) produces significant reduction in inflammation when compared to control group. Methanolic stem extract of T. purpurea (M.S.E.T.) produced significant anti-inflammatory activity. Our results suggest that all the Methanolic stem extract of T. purpurea (M.S.E.T.) possess significant anti-inflammatory activity. Among the three doses of T. purpurea 40 mg/kg body weight showed maximum activity.