DOI: 10.36347/sajp

Pages: 128-137

The purpose of this research was to develop sustained release mucoadhesive films of atenolol by using Hibiscus esculentus polymer & hydroxy propyl methyl cellulose. Various proportions and combinations were fabricated by using solvent casting technique. Various physico mechanical parameters like Physical appearance and surface texture, Drug content uniformity, Surface pH, Weight uniformity, Thickness uniformity, Folding endurance, In vitro drug release, Swelling Index, Mucoadhesive strength were evaluated. In-vitro residence time and Mucoadhesive strength of films was also performed using porcine buccal mucosa. All prepared formulations indicated good physical stability. The possible drug polymer interactions were studied by FTIR studies. The oral route is most popular route for the administration of therapeutic agents because of the low cost of therapy and ease of administration lead to high levels of patient compliance. An ideal film should have the properties like pleasant taste, high stability, ease of handling and administration, no water necessary for application.