DOI: 10.21276/sajp.2016.5.8.5

Pages: 337-341

Leaf extracts of Citrus sinensis have been used in local folk medicine to treat neurological diseases. Its methanolic extracts have sedative activity. Diosmin and Hesperidine have been shown to posses’ anti-inflammatory and analgesic actions. We in the present study tried to evaluate the anticonvulsant property of hydro-ethanolic leaf extracts of Citrus sinensis. It was evaluated in albino mice by Maximal Electric Shock (MES) induced convulsions in mice. The mice were closely observed for 30 minutes and the following parameters were recorded, Onset of convulsion, Duration of convulsion and Time of recovery Percentage of inhibition of seizures compared with standard drug Sodium valproate. With Citrus sinensis 50mg/Kg MES produces single convulsion in 50% of mice with mean onset of convulsion 11.33 sec, mean duration of convulsion 5.0 sec and mean time of recovery 5 sec. With Citrus sinensis 100 mg/kg 33.3% developed convulsion with mean onset of 15.5 sec, mean duration 2 sec and Mean time of recovery 2.5 sec. No mice developed convulsion with standard drug Sodium Valproate. With the increase in dose 50mg/kg and 100mg/kg compared with the control group have shown the time of onset of convulsion prolonged, duration reduced and time of recovery decreased and the values were statistically highly significant P < 0.001. The present study demonstrated that Citrus sinensis possesses anticonvulsant activity against Maximal Electric Shock induced seizures in mice. The anticonvulsant activity was better with dose of 100mg/Kg. However its anticonvulsant properties were inferior to the standard drug sodium valproate. It may act as an adjuvant therapy along with standard anticonvulsant drugs in seizure prevention.