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Scholars Academic Journal of Pharmacy | Volume-5 | Issue-10
Degradation Study of Entacapone Bulk Drug by HPLC with PDA Detector
G. Kumar, T. B. Patrudu, Tentu. Nageswara Rao, M. V. Basaveswara Rao
Published: Oct. 30, 2016 | 246 120
DOI: 10.21276/sajp.2016.5.10.1
Pages: 386-391
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Abstract
A simple and inexpensive method was developed with high performance liquid chromatography with PDA detection for determination of Entacapone. The chromatographic separations were achieved on (250×4.6 mm), 5.0 µm make: X-terra C18 column employing Acetonitrile: 0.1% v/v phosphoric acid in Water (35:65, v/v) as mobile phase at flow rate 1.0 mL/min was chosen. The detector wavelength of 210 nm was employed.