DOI: 10.36347/sjmcr.2015.v03i05.014

Pages: 396-398

Continuous muscle fibre activity or Isaacs’ syndrome is a rare condition which represents more severe phenotype of peripheral nerve hyper excitability. It is characterized by muscle twitching, stiffness& hyperhidrosis. The diagnosis of Isaacs’ syndrome or neuromyotonia is based on clinical features & classical electromyography findings. We report a twenty six year old man complaining of continuous twitching all over his body and increased sweating. General physical & neurological examination was normal except generalized fasciculation’s & hyperhidrosis. Electromyography findings showed classical neuromyotonic & myokymic discharges. The abnormal activity was characterized by doublets, triplets or multiplet single unit discharges that have a high intraburst frequency. This patient was diagnosed as a case of Isaac’s disease & treated with tablet carbamazepine 400 mg per day. His symptoms were gradually improved.