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Scholars Journal of Medical Case Reports | Volume-3 | Issue-05
Continuous Muscle Fibre Activity, Issacs’ Syndrome: A Case Report from Central India
Wakode S L, Wakode N S, Wagh S, Ramteke S G
Published: May 30, 2015 |
188
187
DOI: 10.36347/sjmcr.2015.v03i05.014
Pages: 396-398
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Abstract
Continuous muscle fibre activity or Isaacs’ syndrome is a rare condition which represents more severe phenotype of peripheral nerve hyper excitability. It is characterized by muscle twitching, stiffness& hyperhidrosis. The diagnosis of Isaacs’ syndrome or neuromyotonia is based on clinical features & classical electromyography findings. We report a twenty six year old man complaining of continuous twitching all over his body and increased sweating. General physical & neurological examination was normal except generalized fasciculation’s & hyperhidrosis. Electromyography findings showed classical neuromyotonic & myokymic discharges. The abnormal activity was characterized by doublets, triplets or multiplet single unit discharges that have a high intraburst frequency. This patient was diagnosed as a case of Isaac’s disease & treated with tablet carbamazepine 400 mg per day. His symptoms were gradually improved.