DOI: 10.36347/sjmcr.2015.v03i06.021

Pages: 518-519

Systemic Lupus Erythematosus (SLE) is a connective-tissue disorder commonly affecting females of reproductive age group. Though any organ can be involved by the immunological attack with musculoskeletal, cutaneous and hematological systems being the most common and comprise the majority of presenting manifestations, neurological features as an initial complaints has also been very rarely reported in the literature. High index of suspicion is required to diagnose such cases as other lupus manifestations are lacking and there is no single laboratory test or radiological features that confirm the diagnosis. CNS Lupus should be included in the provisional diagnosis of a female patient of reproductive age group, who presents with complicated neurological manifestations and with no clear-cut clinical, pathological, or image finding. Psychosis and seizures are the only neurological lupus manifestations that are included in American college of rheumatology (ACR) diagnostic criteria for SLE. The ‘’soft’’ symptoms of SLE such as cognitive dysfunction and depression, though the most common, are not included.