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Scholars Academic Journal of Pharmacy | Volume-6 | Issue-03
Preparation and in vitro evaluation of cyclodextrin based piroxicam transdermal gel (release and permeation study)
Qasim Allawi Bader
Published: March 21, 2017 |
143
93
DOI: 10.21276/sajp.2017.6.3.1
Pages: 71-79
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Abstract
Piroxicam; a widely used non-steroidal anti-inflammatory drug(NSAID) , was prepared as a transdermal gel
by mixing with a cyclodextrin in equal amounts and sodium carboxymethyl cellulose (NaCMC) as a matrix polymer in 3
and 6% concentrations. Piroxicam was examined for its melting point and characterized by its fourier transform infrared
(FTIR) spectra and differential scanning calorimetry (DSC). The prepared formulas were tested in terms of their release
and diffusion behavior and compared with a marketed piroxicam gel. The results of the release and diffusion studies were
subjected into different mathematical models to elucidate the pattern and mechanism of their release and diffusion. It was
concluded that (F1) which contain 0.15 g of piroxicam and cyclodextrin in a matrix consist of 3% NaCMC represent the
best one in terms of release and diffusion during the study period where 95% of piroxicam released during 3 hours and
78% of the drug was diffused through cellophane membrane during 4 hours.