DOI: 10.36347/sjmcr.2015.v03i09.031

Pages: 888-891

Primary cold agglutinin disease is usually associated with monoclonal cold-reacting auto antibodies. Disease is chronic and occurs after the fifth decade of life, with a peak incidence in the seventh and eighth decades. Acrocyanosis and Reynaud’s phenomenon usually associated with cold agglutinin syndrome where as Gangrene is a rare complication, usually associated with infections or B-cell lymph proliferative disorders. We present a case of fulminant gangrene of fingers in 50-year-old male with severe Hemolytic Anemia.