DOI: 10.21276/sajp

Pages: 126-138

Pain may be defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. It may vary in intensity (mild, moderate, or severe), quality (sharp, burning or dull), duration (transient, intermittent, or persistent) and referral (superficial or deep, localized or diffuse).Typically, it is a direct response to an untoward event associated with tissue damage, such as injury, inflammation or cancer, but severe pain can arise independently of any obvious predisposing cause (e.g. trigeminal neuralgia) or can persist long after the precipitating injury has healed (e.g. phantom limb pain). In addition some disorders commonly occur in patients who experience pain such as – hyperalgesia (extreme sensitivity to pain stimuli), allodynia (pain in response to non-noxious mechanical stimuli) and hyperesthesia (abnormal sensitivity to sensory stimuli). In recent times, medicinal plants occupy a considerable position for being the paramount sources of drug discovery irrespective of its categorized groups- herb, shrub or tree. The crude methanolic extract of Acacia nilotica bark with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, antihelmentic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment. Analgesic activity of the plant Acacia nilotica was evaluated by acetic acid Induced writhing method. The result showed that the bark extract of plant Acacia nilotica possessed moderate analgesic activity.