DOI: 10.21276/sajp

Pages: 175-185

In the present study Nanosponges were prepared by solvent evaporation method employing Β-Cyclodextrin and HP β-cyclodextrin as a polymer. Gliplizide is taken as model drug for studying various formulations of cyclodextrin based nanosponges. The compatibility of various formulation components was established by Fourier Transform InfraRed (FTIR) spectroscopy. The surface morphology, particle size, production yield, and drug entrapment efficiency of Nanosponges were examined. Shape and surface morphology of the Nanosponges were examined using scanning electron microscopy. Particle size of prepared Nanosponges was observed in the range of 532.9 to 633.5nm. Scanning electron microscopy revealed the porous, spherical nature of the Nanosponges. SEM photographs revealed the spherical nature of the Nanosponges in all variations; however, at higher ratios, drug crystals were observed on the nanosponge surface. Increase in the drug/polymer ratio (1:1 to 1:3) increased their yield (10.23 ± to 35.69), which is in increasing order due to the increase in the concentration of polymer but after certain concentration it was observed that as the ratio of drug to polymer was increased, the particle size decreased, the drug content of different formulations was found in the range 94.4 to 98.6%,the entrapment efficiency of different formulations were found in the range of 78.10 to 94.40%, the maximum drug release of the formulation with HP β cyclodextrin was found to be 99.71%.