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Scholars Academic Journal of Pharmacy | Volume-6 | Issue-05
Assessment of Serum Lipid Profile among Sudanese Patients with Malaria
Ibrahim Yousif Abdalla Hamid, Amina Osman. M. Elzein, Abdelgaidr Eltom
Published: May 26, 2017 |
228
97
DOI: 10.21276/sajp
Pages: 186-190
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Abstract
Changes in lipid profile are seen in many patients infected with malaria parasite. The malaria parasite causes
hepatocellular damage and disturbs lipid handling by the liver. Inside hepatocytes and erythrocytes the parasite replicates
rapidly scavenging cholesterol and lipids required for its growth and metabolism from the host. It also requires host lipids
for detoxification of free heme to form the malarial pigment, haemozoin. Aim to Assess Serum lipid profile in patients
with malaria in Khartoum state. Material and methods the present study was analytical cross-sectional study carried out
during Sep 2016 to Dec 2016, at Khartoum State at alssagai rural hospital. Total of one hundred individuals were
enrolled in this study, and classified into two groups 50 patients with malaria as case group and 50 healthy individuals as
control group. Result as compared there is difference in HDL, LDL, cholesterol and triglycerides between malaria
patients and control subjects (p<0.05). Patients with malaria showed low HDL (20.00 ±3.76mg/dL versus44.52 ± 4.85
mg/dL), low LdL (59.00 ±16.15 mg/dL versus107.76 ±9.76mg/dL), low cholesterol (114.78 ± 16.75mg/dL versus175.34
± 16.83 mg/dL) and elevated triglycerides (172.4 ± 25.63mg/dL versus135.7 ± 11.66 mg/dL). The observations show a
statistically significant. Conclusions malaria infection, both P. vivax and P. falciparum infections, causes derangements
in lipid profile that are characterized by low serum, low HDL, low LDL and high triglyceride levels but differ in total
cholesterol level . These derangements may be of diagnostic, prognostic or therapeutic value