DOI: 10.21276/sajp

Pages: 263-272

A Hyphenated technique is combination or coupling of two different analytical techniques. Which is used as a separation techniques and an online spectroscopic detection technology? . The remarkable improvements in hyphenated analytical methods over the last two decades have significantly broadened their applications in the analysis of biomaterials, natural products, elemental species, explosives, trace elements, etc. and show specificity and sensitivity. in this article recent advance application about hyphenated techniques and information about analytical techniques, GCMS,CE-MS, LC-MS, LC-FTIR, LC-NMR, etc. the different areas like forensic science, environment, biotechnology, geography, pharmaceutical etc. are discussed with appropriate examples for various purpose.