DOI: 10.21276/sajp

Pages: 256-262

Baccaurea ramiflora (family: Euphorbiaceae) is native to Southeast Asia region and is found distributed in the sub-Himalayan tract, mainly from Nepal to Sikkim, Darjeeling hills, Arunachal Pradesh, Tripura, Assam, Bhutan, Burma, Penninsular Malaysia, Tibet and Andaman islands. Microcos paniculata (family: Euphorbiaceae) is a shrub that is abundant in secondary forests and also grown as hedges. As the oil of these plants is extensively used in number of herbal preparation for curing inflammatory disorders, the present study was undertaken to assess analgesic and antiinflammatory activities of its leaves extracts. Dried and crushed leaves of Baccaurea ramiflora and Microcos paniculata were defatted with petroleum ether and then extracted with alcohol. The alcoholic extract at the doses of 200 mg/kg, and 400 mg/kg body weight was subjected to evaluation of analgesic and anti-inflammatory activities in experimental animal models. Analgesic activity was evaluated by acetic acid-induced writhing and hot plate methods in Swiss albino mice; acute and chronic anti-inflammatory activity was evaluated by carrageenan-induced paw oedema and cotton pellet granuloma in Wistar albino rats. Aspirin, Pentazocine and Diclofenac sodium were employed as reference drugs for analgesic and anti-inflammatory studies, respectively. In the present study, the alcoholic leaves extracts of Baccaurea ramiflora and Microcos paniculata demonstrated significant analgesic and anti-inflammatory activities in the tested models