DOI: 10.36347/sjams.2018.v06i12.011

Pages: 4683-4688

Laryngoscopy and endotracheal intubation is associated with hemodynamic changes due to activation of nerves present in the oral cavity and beyond. Most commonly hypertension and tachycardia is seen other cardiac changes are also common like arrhythmias, asystole etc. Various methods are used to attenuate this hemodynamic response. In present study, we have used oral clonidine 90 minutes before the surgery to attenuate this reflex response. This randomized control study was conducted on 60 patients of ASA grade 1 and 2 after taking ethics committee approval. Patients were divided into two groups. In Group 1 (n=30), patients received clonidine orally one and half hours prior to surgery and Group 2 (n=30), patients received Placebo orally one and half hours prior to surgery. Diastolic, systolic and mean blood pressure and heart rate were measured throughout the procedure and recorded for five minutes just after the intubation. Oral clonidine given pre-emptively helps attenuating adverse hemodynamic response occurring due to laryngoscopy (p<0.05) in comparison to control group. Oral clonidine given pre-emptively reduces adverse hemodynamic response occurring due to laryngoscopy