DOI: 10.36347/sjams.2018.v06i12.042

Pages: 4844-4847

MMPs play important role in the pathogenesis of periodontitis by degrading the extracellular matrix. A relatively new approach –host modulation therapy (HMT) may be beneficial in modulating the host response to these inflammatory mediators. Sub antimicrobial dose Doxycycline can be used to antagonize the activity of MMPs. The aim of the study was to evaluate the effectiveness of SDD as an adjunct to NSPT. 40 patients with chronic periodontitis were included in this randomized double blind parallel group clinical study. After fulfillment of inclusion criteria subjects were divided into two groups by simple random sampling; cases and controls. At baseline clinical parameters were recorded and NSPT was carried out in both groups. Cases were advised to take SDD 20mg for 3 months. Both the groups were again evaluated at 3 months and at the end of 6 months. Clinical parameters improved significantly in both the groups but significant reduction in PD, BOP and RAL was seen in NSPT+SDD group compared to control group. SDD can be regarded as effective adjunct to NSPT in treatment of chronic periodontitis as appreciated by improvement in clinical parameters.