DOI: 10.21276/sajp

Pages: 346-358

Diabetes mellitus is a multifactorial disease which is characterized by hyperglycemia, lipoprotein abnormalities, raised basal metabolic rate, defect in reactive oxygen species scavenging enzymes and altered intermediary metabolism of major food substances. Diabetes is a major degenerative disease in the world today, affecting at least 150 million people and having complications which include hypertension, atherosclerosis and microcirculatory disorders. The crude methanolic extract of Acacia nilotica bark with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, anthelmintic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment. Hypoglycemic activity of the plant Acacia nilotica was evaluated and the result depicted that the Methanolic crude extract, Dichloromethane fraction at a dose of 400mg/kg body weight showed significant hypoglycemic activity compared to the standard.