DOI: 10.21276/sasjm.2018.4.4.1

Pages: 51-56

Cancer of the colon is one of the most common cancers in developed countries and its chemoprevention is of great interest throughout the world. We have investigated the efficacy of kolaviron on xenobiotic-metabolizing enzymes against 1,2 dimethyl hydrazine (DMH)-induced colon carcinogenesis. Male albino Wistar rats were randomly divided into four groups. Group 1 served as control, animals have access to rodent feeds for 8 weeks plus 1mM EDTA-saline injection subcutaneous (s.c) once a week for 4 weeks. Group 2 rats served as kolaviron (KV) control received 100 mg/kg body weight of kolaviron per oral (p.o.) every day. Group 3 served as carcinogen control, received pellet diet and 30 mg/kg bodyweight of 1,2- dimethylhydrazine (DMH) dissolved in 1mM EDTA-saline subcutaneous injection once a week for 4 weeks to induce colon carcinogenesis. Group 4 rats received 30 mg/kg body weight DMH dissolved in 1mM EDTA-saline subcutaneous injection and kolaviron 100 mg/kg body weight. DMH exposure showed elevated activities of phase I enzymes and reduced activities of phase II enzymes in the liver and colon of colon carcinogenesis bearing rats.