DOI: 10.36347/sjams.2017.v05i06.051

Pages: 2313-2319

Breast cancer is the most common cancer among women and most common cause of cancer related mortality and morbidity. Breast cancer oncogenesis has many pathways involved. Caveolin-1 is a component of the caveolae and is the key molecule involving strategic signalling molecules in the pathogenesis of breast cancer. The aim of the present study is to evaluate the distribution of Caveolin-1 antigen in specimens obtained from benign and malignant breast cancers. On this study tissue samples obtained from benign breast disease (n=203) and malignant breast disease (n=98) was subjected to immunohistochemical staining and positive areas separately for stromal components and epithelial component of the tumour.Caveolin-1 expression was 1746.78±981.89 and 1457.31±1331.91 in the benign and malignant tumour groups respectively. When the benign group was evaluated independently; it was observed that highest expression was observed in the sclerosing adenosis. Among the malignant breast cancer group invasive ductal carcinomas and mucinous carcinoma had the highest expression. Stromal comments were stained predominantly. Caveolin-1 expression loss was seen in malignant lesions. This suggests the tumour suppressor function of this gene for mammary carcinoma oncogenesis.