DOI: 10.21276/sajp.2017.6.9.5

Pages: 403-409

Synedrella nodiflora (L) Gaertn, commonly known as Pig grass, Cinderella weed, node weed is a species of flowering plant in the family of Asteraceae. It is a medicinal plant mostly used in the herbal medicine to cure leprosy, swelling, constipation, dysentery and diarrhea. Ethanol leaves extract of Synedrella nodiflora were investigated on in-vitro antioxidant, antimicrobial and laxatives activities in albino rats and were compared with the standard drugs Ascorbic acid(100mg/kg), Ciprofloxacin(40mg/kg) and Ducox(300mg/kg) respectively. The extract were administered based on high and low doses, 2000,1000,500,250,125 and 62.5mg/ml. Different models such as DPPH radical scavenging activity, Nitric oxide scavenging activity and Anti-lipid peroxidation activity were used to determine antioxidant activity. Healthy adult wistar albino rats of both sex weighing 150-200g was used to determine laxative effect of the ethanol leaves extract, for the antimicrobial activity, clinical strains of microorganism used for the study includes: E. coli, Proteus mirabilis, Pseudomona aeruginose, Staphylococcus aureus, Salmonella typi and Klebsiella pneumonia. The agar disc diffusion method was used and zone of inhibition recorded also minimum inhibitory concentration was determined.