DOI: 10.36347/sjams.2017.v05i06.063

Pages: 2388-2392

Previous studies are there showing Nalbuphine used intrathecally as an adjuvant to bupivacaine but no study clearly stated the most effective dose of nalbuphine with minimum side effects. Levobupivacaine is less cardiotoxic and there are few studies using nalbuphine with levobupivacaine. The purpose of this study was to compare different block characteristics, hemodynamic effects, postoperative analgesia, and adverse effects of different doses of nalbuphine when used intrathecally with hyperbaric levobupivacaine for spinal anesthesia. The patients were randomly allocated into four groups (30 patients each). Group 1 received levobupivacaine (0.5%) 2.5 with normal saline, group II received Isobaric Levobupivacaine (0.5%) 2.5 ml plus nalbuphine 0.5 mg total made to 3 ml Group III received Isobaric Levobupivacaine (0.5%) 2.5 ml plus nalbuphine 0.75 mg total made 3 ml ,Group IV received Isobaric Levobupivacaine( 0.5% ) 2.5 ml plus nalbuphine 1 mg diluted and total made to 3 ml. The onset and duration of sensory and motor block, the regression time of sensory and motor block, hemodynamic changes, and side effects were recorded. Patients in Group III and IV had significantly longer sensory and motor block than patients in Groups I and II. Side effects were more with group III and IV compared to group I and II. Intrathecal nalbuphne (0.75mg and 1mg) was associated with prolonged motor and sensory block, compared to 0.5mg and levo bupivacaine alone.