DOI: 10.21276/sajp.2017.6.10.5

Pages: 440-445

The aim of the present study was to formulate and evaluate Pravastatin Sodium transdermal patch. Pravastatin is a lipid lowering agent, because of its short biological half life (t1/2, 1-3 hours) only 18% of its dose reaches to the systemic circulation of the blood on oral administration. Hence it is a suitable drug to formulate into transdermal form. Transdermal patchs of Pravastatin Sodium was prepared by using different polymers like HPMC 3000, HPMC K15M,HPMC E5 by solvent casting method. FTIR study reports have shown that there was no interaction between drug and excipients. The prepared patches were evaluated for Folding Endurance, Uniformity of weight, Drug content, Moisture content, In-vitro diffusion study, a series of 12 formulations were prepared by using different polymers composition in different concentrations among them F11 formulation prepared by using HPMC K15M was showed satisfactory results with 88.6% of drug release in diffusion studies was found to be suitable for formulating as transdermal patch in order to increase the bioavailability and to decrease the dosing frequency of Pravastatin Sodium.