DOI: 10.21276/sajp.2017.6.11.2

Pages: 454-459

Ayachendooram (AC), a widely used Siddha metallic preparation consist of purified iron fillings, vinegar and odina bark juice. The formulation was evaluated for acute and chronic toxicity in rats with reference to histopathological, haematological, and bio chemical parameters and detection of iron from the various tissues of rats. During acute toxicity study, there were no any adverse effects found in the general behaviour and mortality at any dose level given. In chronic toxicity studies (90days) Ayachendooram in various dose level (18, 90, and 180 mg/kg B.wt) did not cause any changes in hematological and biochemical parameters with exception of a transient rise in uric acid, albumin, SGOT and lymphocyte level. The changes observed were significant only at the highest dosage of 180 mg/kg B.wt. Excepting albumin level, which increased with average dose (90mg), which was not significant when compared to control. Feed and water intake failed to reveal any marked changes in chronic toxicity studies. Histopathological lesions were non-specific in all organs between treated and control group except in liver revealed mild changes with highest dose level. In the present study the drug possessed no toxic effect upto 180 mg.