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Scholars Academic Journal of Pharmacy | Volume-12 | Issue-03
Analysis of Methylcobalamin and Hydroxocobalamin by HPLC/MS. Method Validation
Stanislav V. Yefimov
Published: March 22, 2023 | 284 758
DOI: 10.36347/sajp.2023.v12i03.003
Pages: 67-73
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Abstract
Previously, we found that methylcobalamin spontaneously converts to hydroxocobalamin at room temperature in aqueous and methanol solutions protected from light. The kinetics and rate constants were determined. This work is devoted to the validation of the method for the quantitative determination of methylcobalamin and hydroxocobalamin in pharmaceutical preparations.