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Scholars Academic Journal of Pharmacy | Volume-6 | Issue-12
Synthesis and Anticancer Activity of Some New Stilbene Derivatives
Rathnakar Reddy Kotha, Anil Kumar Garige, Achaiah Garlapati
Published: Dec. 30, 2017 | 89 78
DOI: 10.21276/sajp.2017.6.12.2
Pages: 482-491
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Abstract
The present study was aimed to synthesize derivatives of cis stilbene and evaluate for their anti-cancer activities. Several cis stilbenes with substitutions on the olefinic carbon were synthesized and characterized by IR, NMR, and MASS spectra. Some compounds from each series were evaluated for their cytotoxicity against MCF-7 and HeLa cell lines. Among all the compounds, compound 4c with methyl ester group on olefinic carbon exhibited potent activity against MCF-7 and HeLa cell lines with IC50 values 22.24µM and 27.43µM respectively.