DOI: 10.21276/sasjm.2018.4.5.1

Pages: 64-68

Intrathecal opioids increase postoperative analgesia “to compare the clinical and anaesthetic effects between intrathecalnalbuphine and fentanyl with hyperbaric bupivacaine for post-operative analgesia in caesarean section" Hospital based interventional prospective study. Sample size was calculated , 55 subjects for each of two groups at α error 0.05 and power 80% assuming difference to be mean detected in duration of analgesia in both nalbuphine & fentanyl group( 11±20 ) as per seed article. 110 eligible patients undergoing caesarean section on first come first serve basis and were allocated in 2 groups using chit in box method. The onset of complete motor block was significantly more rapid in fentanyl group than in nalbuphine group. The duration of post-operative analgesia was more prolonged in nalbuphine group. There is significant difference was found between both groups as regards the duration of sensory block, motor block, duration of analgesia, No significant difference was found in Apgar score, hemodynamic parameters and oxygen saturation. Adverse effects were less common in nalbuphine group but the difference was insignificant. We conclude that intrathecalnalbuphine 0.8 mg is effective in enhancing postoperative analgesia as compare to intrathecal fentanyl.