DOI: 10.21276/sajp.2017.6.12.9

Pages: 536-545

Epilepsy is the term used for a group of disorders characterized by recurrent spontaneous seizures that apparently result from complex processes involving several neurotransmitter systems such as glutamainergic, cholinergic, and gabaergic system. Seizures can arise from virtually any cerebral pathology that increases the excitability of brain tissue. The etiologies can be divided into genetic and acquired brain lesions. Emblica officinalis is plant and which is well known fruit and it is called as Usiri or usirikai(Telugu), amalika (Sanskrit), aamla (Hindi), aamla (Gujarati), aavalaa (Marathi), amloki (Bengali), Aula (Punjabi), nellikka (Malayalam), nellikkai (Tamil and Kannada). The present study is aimed to evaluate the anticonvulsant activity of Fruit and leaf extracts of Emblica officinalis by Strychnine Induced Convulsions in Mice Model. Here the animals are divided into nine groups Phenytoin sodium 40mg/kg p.o is used as for standard group and test groups received low dose 200mg/kg p.o, medium dose 400mg/kg p.o, high dose 600mg/kg p.o for Fruit and leaf extracts respectively. The results demonstrate the strong anticonvulsant activity of Emblica officinalis fruit and leaf extracts (200, 400 & 600 mg/kg) in strychnine induced convulsions. The present study provides the benefits of Emblica officinalis fruit and leaf extracts using in the treatment of epilepsy