DOI: 10.36347/sjmcr.2016.v04i09.017

Pages: 687-691

Ameloblastoma is a true benign neoplasm of odontogenic epithelial origin. It is the second most common odontogenic neoplasm. It comprises of approximately 1% of all oral tumors and 18% of all odontogenic tumors. Ameloblastomas present with a wide range of clinical and radiological behaviors which makes it the most significant odontogenic neoplasm. There are many histopathological variants of ameloblastoma amongst which hybrid ameloblastoma which is a combination of various histological variants is the rarest type. Up to our knowledge 26 cases have been reported in the literature so far. Generally in hybrid ameloblastoma there is a combination of desmoplastic and follicular variants histologically but sometimes three or more histological variants are also seen in this type. We present a case of 50 year old male patient who presented with a huge mandibular ameloblastoma which was resected along with hemimandibulectomy and reconstructed with iliac crest graft and reconstruction plate. Histopathological examination revealed presence of stromal desmoplsia and osteoplasia with classical follicular islands, granular and acanthomatous differentiation in collision with luminal and intraluminal unicystic ameloblastoma with features of COC ex ameloblastoma.