DOI: 10.36347/sjmcr.2016.v04i12.010

Pages: 913-914

POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) syndrome is a rare disorder of plasma cell. A 57 years old man admitted to our clinic with complaints of legs pain and weakness. He had sclerodactly and hypopigmented lesions was on the fingers and legs. The patient's laboratory data were indicative of anemia, high sedimentation rate and elevated plasma IgG level. M spike was determined in protein electropheresis. A monoclonal band of IgG-kappa was detected in serum and urine immunoelectropheresis. Electromyography showed sensorio-motor polyneuropathy in bilatheral lower extremity. A computed tomography scan showed sclerotic bone lesion in left femur. Combined chemotherapy (lenalidomide 25 mg once daily oral on days 1-21 and dexamethosone 40 mg/day days 1-4 of repeated 28-day cycles) was started to our patient for POEMS syndrome. The symptoms of neuropathy decreased after 2 months. M spike was decreased in protein electropheresis. The patient with POEMS syndrome generally are diagnosed late because of this syndrome is rare. We should think POEMS syndrome in patient with neuropathy and clonal plasma disorder.