DOI: 10.21276/sajp.2018.7.1.7

Pages: 47-53

Multiple Intravenous drug administered in one route cannot be avoided in critical care as the need for various drug is higher than the amount of venous access, therefore this study is aimed at assessing the physicochemical compatibility and stability of fluconazole in infusion fluids over time. Two different brands of fluconazole infusion were reconstituted with Ringer‟s lactate solution (400 µg/mL), 5% Dextrose water (400 µg/mL) or Sodium bicarbonate injection (2mg/mL) in a separate polyvinyl chloride containers. The reconstituted samples were visually inspected for colour, odour changes, presence of particulate matter, and then assayed using a UV-Visible Spectrophotometric method in triplicate at time 0, 0.5, 1, 2, 8, and 24 hrs. The pH was further monitored at predetermined time interval. The reconstituted samples showed no colour or odour change and no particulate matter. The concentration of un-degraded fluconazole in the reconstituted samples remain > 90% of the initial amount (t = 0) Thus, indicating no physical interaction between fluconazole, infusion fluids and the packaging material. The results obtained in this study indicate that infusion of reconstituted fluconazole with any of the infusion fluid used in this study is safe, stable and compatible within the 24 hr experimental period.