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Scholars Academic Journal of Pharmacy | Volume-7 | Issue-02
Effects of Ethanolic Extract of Bauhinia Variegata Leaves Alone and In Combination with Metoclopramide on Induced Model of Acute Colitis in Rabbits
Mustafa Hussein Sachit, Ahmed Rahma Abu Raghif, Shihab Abdul Rhman Shihab
Published: Feb. 28, 2018 |
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122
DOI: 10.21276/sajp.2018.7.2.5
Pages: 92-98
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Abstract
The exact reasons of UC are still unidentified; however, numerous factors have
been implicated in the pathophysiology of the disease. Inflammatory mediators such as
cytokines, reactive oxygen species, also 5-HT plays a key task in the pathogenesis of UC.
The available drugs for the treatment of UC have considerable systemic side effects.
Therefore, there is a pressing need for the development of new therapeutic agents for the
treatment of UC, Thus, the evolution of a new safe, effecient and cheap medicine is
required. The aim of current study is to investigate the effect of ethanolic extract of
Bauhinia variegates alone or in combination with metoclopramide on inflammatory
biomarkers, oxidative stress parameters and histopathological score in experimentally
induced colitis. This study was conducted on thirty six male albino weighting about
(1000-1750) g rabbits were brought from animal house previously submitted to starvation
for at least 12hrs.