DOI: 10.21276/sajp.2018.7.2.5

Pages: 92-98

The exact reasons of UC are still unidentified; however, numerous factors have been implicated in the pathophysiology of the disease. Inflammatory mediators such as cytokines, reactive oxygen species, also 5-HT plays a key task in the pathogenesis of UC. The available drugs for the treatment of UC have considerable systemic side effects. Therefore, there is a pressing need for the development of new therapeutic agents for the treatment of UC, Thus, the evolution of a new safe, effecient and cheap medicine is required. The aim of current study is to investigate the effect of ethanolic extract of Bauhinia variegates alone or in combination with metoclopramide on inflammatory biomarkers, oxidative stress parameters and histopathological score in experimentally induced colitis. This study was conducted on thirty six male albino weighting about (1000-1750) g rabbits were brought from animal house previously submitted to starvation for at least 12hrs.