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Scholars Academic Journal of Pharmacy | Volume-7 | Issue-03
Effect of Telmisartan on Learning and Memory in Albino Rats
Uma Shanker Prasad Keshri, Sumit Kumar Mahato, ManjuGari, Akhilesh Kumar, Rajiv Kumar
Published: March 30, 2018 |
136
83
DOI: 10.21276/sajp.2018.7.3.5
Pages: 134-138
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Abstract
Dementia is a syndrome of gradual onset and continuous decline of higher
cognitive function. By 2050, more than 115 million people will have dementia. The
prevalence of dementia rapidly increases from about 2-3% among those aged 70–75 years
to 20–25% among those aged 85 years or more. Etiology of dementia is Alzheimer’s
disease (AD), vascular dementia, and other neurodegenerative disease. Discovery of
complete Renin angiotensin system (RAS) in the brain, and Potential function of Ang II
in the etiology of certain neurodegenerative diseases, including Alzheimer’s and
Parkinson’s disease, seizures, and the development of metabolic syndrome and diabetes.
Telmisartanpossess partial peroxisome proliferators’ activator receptor gamma (PPAR)
agonistic activity. PPAR-γ agonists have been reported to effectively attenuate oxidative
stress, inflammation and apoptosis in the central nervous system (CNS). Wister albino
rats weighing between 150-250 grams were taken for the present study. Rats were divided
in five different groups,