DOI: 10.21276/sajp.2018.7.5.3

Pages: 203-207

When taking oral medications, it is recommended to take them with cold or warm water. However, if medication is taken regularly and the timing of ingestion is after meals, there are likely many cases in which the medicine was taken with fruit juice, tea, coffee, non-alcoholic drinks, and alcoholic drinks. The contents of non-alcoholic beverages are usually hidden and protected by law; therefore, unknown substances may impact the proliferation and function of gastrointestinal epithelial cells. The highestselling non-alcoholic drink is Coca-Cola (2017), and its sales are third in Japan (2017). Therefore, drug intake by Coca-Cola is considered to be greater than that by other nonalcoholic drinks. In this study, to clarify the influence of Coca-Cola on gastrointestinal epithelial cells, we examined the influence of Coca-Cola on the proliferation and cellular uptake of HGC-27, IEC-6 and Caco-2, which are gastrointestinal epithelial cell lines. In the limited conditions (Concentration of Coca-Cola: 4%, Exposure time of Coca-Cola: 6 hr), significant changes in the proliferation of human gastrointestinal epithelial cells or uptake were not observed.