DOI: 10.21276/sasjm.2018.4.6.1

Pages: 72-81

The epidemiological data of various lipid profile abnormalities in subclinical hypothyroidism in Jammu is scarce. In fact the entity of subclinical hypothyroidism is still not well recognized itself. We conducted a prospective case control study was conducted in the Department of Medicine, in Acharya Shri Chander College of Medical Sciences, Jammu, from November 2011 to October 2012. Lipid profile abnormalities of seventy patients with subclinical hypothyroidism were compared with 100 age and sex matched controls. Mean age of the patients with subclinical hypothyroidism was 38.83±11.60 years with a majority being females. The most common symptom in subclinical hypothyroid patients was easy fatigability present in 24.2% of the cases followed by weight gain in 14.3% and constipation in 12.8%. Mean TSH levels in cases with subclinical hypothyroidism was 9.16±2.99 µIU/ml. 47 patients (67%) with subclinical hypothyroidism had TSH ≤ 10 µIU/ml. 23 patients (33%) had TSH >10 µIU/ml. The mean serum triglyceride levels in cases was 146.37±31.50 mg/dl which was significantly higher than mean serum triglycerides of controls (133.85±25.43mg/dl) (p value=0.0048).Cases with subclinical hypothyroidism had a mean serum LDLcholesterol value of 117.79±32.43 mg/dl as compared to euthyroid controls who had a mean serum LDL-cholesterol value of 93.69±25.06mg/dl. This was found to be statistically significant with a p value<0.0001.