DOI: 10.21276/sajp.2018.7.6.7

Pages: 254-259

The aim of this study was concerned with analysis of swelling, erosion and release behaviour of hydrophilic matrix tablets containing different grades of hydroxy propyl methyl cellulose (HPMC); i.e. HPMC K100 LV Premium, HPMC K4M & HPMC K100M in the preparation of controlled release tablets. Prazosin Hydrochloride (PHCl) was used as a model drug. Tablets were prepared by direct compression method. After evaluation of all physical parameters, swelling, erosion and release behaviour of hydrophilic matrix tablets were carried out in phosphate buffer pH 7.4. Viscosity of HPMC played a major role in controlling swelling and erosion profile. Swelling data revealed that the matrices of F1 swelled for 6 - l2 hrs and then retained a near constant volume. F1 showed increased swelling with an increase in the concentration of HPMC in the matrix, but the change was found insignificant (P˂0.05) above 60% w/w. The matrices eroded within 16 hrs in the dissolution medium. Formulation of batch F4 exhibited a much slower rate in swelling and erosion which extended up to 24 hrs. Due to high viscosity of HPMC K100M with DCP and suitable as controlled release system.